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 Ask
Dr. Aron
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 Will
my second baby have Celiac?
Please help. I am 7 months pregnant,
and my 3 year old child was diagnosed
with celiac shortly after my husband
and I found out about the pregnancy.
I asked his GI doctor what to do
about preventing the onset of celiac
with our second child and she knew
very little to tell me.
I would like to know the percent
chance that baby #2 will have celiac.
Child #1 is the only person in the
family with it as far back as we
know.
Should I breastfeed this baby? Do
I need to be on a gluten free diet
when breastfeeding? When should
I introduce gluten in baby #2’s
diet?
|
 The
best answer appears in the British
Journal “Gut” 25 April
2007, from Bourgey, M et al. You
must test yourself, your husband,
and your first baby for HLA-DQ2
and HLA-DQ8 genes. The lab must
test for the alleles, or components
of these genes.
If you or your husband both have
HLA-DQ2 with 2 copies of DQB1*0201,
then there is a grerater than 80%
chance that the new baby will have
celiac disease. If the alleles of
you and your husband are DQB1*0201
and DQA1*0501 and in a trans position,
then there is a 68% chance for the
baby. If these alleles are in a
cis position, then a 23% chance
is possible. If both of you have
DQB1*04, then there is a 1% chance.
If there is one copy of DQ8 and
one copy of either DQB1*02 or DQA1*05
then a 1 in 50 chance.
You will need to contact Prometheus
Labs in San Diego to get these
tests.
Breast feeding
is safe and even helpful. You
should be on a gluten-free diet
while breast feeding. Do not introduce
gluten until solid food is taken,
which is usually after 6 months.
Good Luck.
Health
and happiness,
Dr. Aron, AUGUST
10 , 2007
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