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 Ask
Dr. Aron
|
 Can
IgA level affect Celiac testing?
Is it
common for kids (my son is 2.5)
to have false negatives? How
much does his IgA level affect
the testing? My son has never
had growth issues, is it still
possible for his symptoms to
be caused by Celiac? Can Celiac
be jump started by rota-virus?
Can the testing be misread?
Sorry for all the questions,
but my son (2.5) has had chronic
diarrhea, as well as many other
issues, since he was hospitalized
with rotavirus. After 2 endoscopes
the cause of his problems is
still undiagnosed. He is IgA
deficient, but nobody has mentioned
much about that, but I have
read that can affect the testing.
|
 Since
the tTG antibody test is an IGA
antibody, IgA deficiency will
make the tests falsely negative.
An IgG tTG test would be helpful,
as would HLA DQ2, DQ8 genetic
studies. If any of those are positive,
he needs an intestinal biopsy.
He may well have post-infectious
irritable bowel syndrome, especially
if there was stress at the time
of the initial rotavirus infection.
Very low doses of aminosalicylates
such as balsalazide (use about
250mg in applesauce) daily could
help.Health
and happiness,
Dr. Aron, Dec
08
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